The Mondo puzzle series by Cactus on YoYoGames is incredibly famous and featured.
Mondo Medicals is the first game in the series by Cactus, and it introduces a hospital puzzle setting, where the player is being tested during the research for the cure for cancer.
This time the player is a secret agent trying to protect the president from the 'laser indians'. While still puzzle-oriented, it also includes typical First Person Shooter gameplay when the player fights the notorious laser indians.
An upcoming Mondo game has been announced by Cactus... and a trailer can be found here: http://www.youtube.com/watch?v=XndB2tHQDBE